Life-Coherent Systems Immunology
Reseeing Chronic Immune Disease as Organism–Niche Phase-LockingBy Dr Bichara Sahely
Length11h 59m
About this audiobook
Life-Coherent Systems Immunology offers an organism-centered way to understand chronic immune-mediated disease. Rather than seeing immunity mainly as a war against non-self, it reframes immunity as the living process by which the organism conserves boundary-coherence while remaining open to the world. Autoimmunity, allergy, autoinflammation, fibrosis, chronic inflammation, and post-infectious illness are understood not only as diagnostic categories, but as possible signs of maladaptive organism–niche phase-locking. Defence, inflammation, repair, memory, or conservation may become stuck, preventing return to ordinary living. Drawing on autopoiesis, 5E cognition, salutogenesis, allostasis, immunometabolism, mitochondria, tissue niches, exposure ecology, public health, and civilization, this book offers a deeper clinical grammar: name the disease, but also understand the locked living process — and the conditions that allow life to move again.
Audiobook details
GenreHealth and Wellness
Length11 hrs 59 mins
Narrated byListen with 1,000+ voices
FormateBook with Audio
Publish dateMay 15, 2026
LanguageEnglish
Table of contents
1Chapter 1
2Audiobook Note
3Prefatory Note
4Executive Summary
5Part I. Re-Seeing Immunity
Show all chaptersShow less
61. Introduction: Why Immune Disease Requires a Deeper Clinical Grammar
72. Observer Humility: Distinctions as Instruments, Not Possessions
83. From Observer-Centered Immunology to Organism-Centered Immune Coherence
9Part II. The Immune System as 5E Organismic Cognition
104. Immune Cognition as Embodied, Embedded, Enactive, Extended, and Evaluative
114.1 Embodied Immunity
124.2 Embedded Immunity
134.3 Enactive Immunity
144.4 Extended Immunity
154.5 Emotive and Evaluative Immunity
165. Preservation, Development, and Coherence: The Attractor Logic of Immune Life
175.1 Preservation: Boundary, Defence, Containment, and Memory
185.2 Development: Openness, Tolerance, Symbiosis, Growth, and Repair
195.3 Coherence: Flexible Movement Between Protection and Participation
205.4 Pathological Lock-In of the Attractors
215.5 Clinical Meaning of the Attractor Logic
22Part III. Health, Healing, and Phase-Locking
236. Salutogenesis: Coherence, Meaning, and Resistance Resources
247. Naviaux’s Health Cycle and Healing Cycle
257.1 The Health Cycle
267.2 The Healing Cycle
277.3 Re-entry into the Health Cycle
287.4 Disease as Failure of Re-entry
298. Allostasis, Allostatic Load, and Immune Resilience
308.1 Homeostasis and Allostasis
318.2 Allostatic Load
328.3 Immune Resilience
338.4 Phase Coherence
348.5 Clinical Implications of Allostatic Reasoning
359. The Master Distinction: Adaptive Phase-Shifting versus Maladaptive Phase-Locking
369.1 The Immune-Metabolic Phase Cycle
379.2 Adaptive Phase-Shifting
389.3 Maladaptive Phase-Locking
399.4 Phase-Locking and the Organism–Niche Relation
409.5 Phase-State Clinical Reasoning
419.6 The Ethical Meaning of Phase-Locking
429.7 Transition to Mechanisms
43Part IV. Molecular, Cellular, and Evolutionary Foundations
4410. Molecular Architecture: Sensors, Signals, and Regulons
4510.1 Pattern-Recognition Receptors and Boundary Evaluation
4610.2 Antigenicity, Adjuvanticity, and Context
4710.3 Inflammasomes and the Danger-Defence Transition
4810.4 cGAS–STING and Nucleic-Acid Boundary Integrity
4910.5 Fc Receptors, Complement, and Immune-Complex Meaning
5010.6 Mechanosensors and the Immunology of Force
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