Derek Chance, the world's second-best assassin, crashes into his ex-girlfriend Natasha (the actual best) on a job, discovering they've been set up by The Syndicate. Forced to partner up, they disrupt a biological weapon auction, survive bounties on their heads, and wage war on The Syndicate's operations. Through explosions, firefights, and constant bickering, they rebuild their partnership and relationship, becoming the deadliest and most entertaining assassination duo in the business.