'McTeague: A Story of San Francisco' is a novel by Frank Norris that tells the story of a simple and naive dentist, McTeague, who lives in San Francisco. His life takes a dramatic turn after he marries his best friend's cousin, Trina. They win a lottery, but this fortune brings out the worst in them, leading to greed, violence, and eventual fall. The book provides a stark illustration of human nature and the destructive power of unchecked desires.