6Introduction of the Word “Gout”
112The Cause of the Inflammatory Phenomena
7Early Views as to the Nature of Tophi
113Non-Toxicity of Uric Acid
8The “Honour of the Gout”
114Are the Precursors of Uric Acid Toxic?
9That Gout confers Immunity from other Disorders
115Suggestion of a Specific Infection
10Growing Infrequency and Attenuation of Gout
116Local Foci of Infection
11Isolation of Acute Articular Rheumatism From Gout
117Summary
12Tardy Dissociation of Chronic Gout From Chronic Rheumatism
118Analysis of the Acute Paroxysm
13Identification of Muscular Rheumatism
119The Evolution and Life History of Gout
14Differentiation of Chronic Gout From Arthritis Deformans
120Analogies between Gout and the Specific Infective Arthritides
15Cleavage of Arthritis Deformans into Two Types
121Correlation of the Metabolic Phenomena of Gout with the Postulated Infective Element
16Elimination of the Infective Arthritides
122Acute Localised Gout
17Garrod’s Theory
123Prodromal Symptoms
18Antagonistic Views
124The Acute Paroxysm
19Histogenous Theories
125Detailed Consideration of Phenomena
20Antecedent Structural Changes
126Acute Generalised Gout
21Hepatic Inadequacy
127Collateral Phenomena of Gout
22Hyperpyræmia
128Incidence of Gouty Stigmata in Various Types of Fibrositis
23Nervous Theories
129Chronic Articular Gout
24Growing Scepticism as to Garrod’s Pathogeny of Gout
130The Joint Deformities of Chronic Gout
25Definition and Classification
131Tophi: Their Evolution and Distribution
26Classification
132Other Sites of Tophi
27Suggested Classification of Articular Gout
133Affinities Between Gout and Other Diseases
28Etiology and Morbid Anatomy
134Gout in Relation to Glycosuria
29Summary
135Gout in Relation to Phlebitis
30Morbid Anatomy
136Cutaneous Disorders
31Revelations of the Bio-Chemist
137Gout and Nephritis
32Protein Metabolism
138Prognosis in Gout
33The Formation of Urea
139Articular Gout
34Fate of the Amino-Acids
140Etiological Diagnosis
35Seat of Formation of Urea
141Introductory Remarks
36Amino-Acids in Relation to Gout
142The Diagnostic Status of Tophi
37The Glycocoll Theory of Gout
143Tophi in Relation to Arthritis
38Urea Excretion in Gout
144Frequency of Tophi in True Gouty Arthritis Underestimated
39Creatine and Creatinine
145Difficulty of detecting Tophi
40Inborn Errors of Metabolism
146Acute Articular Gout—Localised Variety
41The Isolation of Nucleic Acid
147Differential Diagnosis
42Researches on Spermatozoa
148Gout in the Big Toe
43The Discovery of Purins
149Static Foot Deformities
44Uric Acid a Derivative of Nucleic Acid
150Gout in the Instep
45The Chemistry of Uric Acid and the Purin Bodies
151Gout in the Heel
46Chemical Constitution
152Local Sources of Fallacy
47Structural Formulæ
153Gout in the Sole
48Properties of Uric Acid
154Anomalous Sites for Initial Outbreaks
49Uric Acid in the Blood
155Acute Gouty Polyarthritis
50Gudzent and Schade’s Theories
156Differential Diagnosis
51Organic Combinations
157Acute Articular Rheumatism
52Complexity of the Problem
158Acute Gonococcal Arthritis
53Exogenous Purins
159Secondary Syphilitic Arthritis
54Exogenous Uric Acid Excretion
160Acute Rheumatoid or Atrophic Arthritis
55Fate of the Unexcreted Purin
161Infective Arthritis of Undifferentiated Type
56Endogenous Purins
162Chronic Articular Gout
57Source of Endogenous Purins
163Chronic Monarticular Gout
58Proteins and their Derivatives
164Monarticular Gout in Large Articulation a Rarity
59Amino-Acids and Dicarboxylic Amino-Acids
165Chronic Gout of Oligo-articular Distribution
60Endogenous Uric Acid Excretion
166Its Confusion with Chronic Villous Synovitis
61Factors Influencing Endogenous Uric Acid Excretion
167Villous Synovitis Static and Non-gouty in Origin
62Physiological Conditions
168Clinical Symptoms of Villous Synovitis
63Pathological States
169Chronic Gout of Polyarticular Distribution
64Synthetic Formation of Uric Acid
170Differential Diagnosis
65Distribution of the Enzymes
171Osteoarthritis
66Stages in Disruption of Nucleic Acid
172Local Characters of Joint Swellings
67Destruction of Uric Acid
173Rheumatoid Arthritis
68Uric Acid Excretion in Gout
174Local Characters of Joint Swellings
69Uric Acid Variations in Acute Gout
175Nerve Arthropathies
70Uric Acid Variations in Chronic Gout
176Hæmophilic Arthritis
71Retarded Exogenous Uric Acid Output
177Skiagraphy
72Lowered Endogenous Uric Acid Output
178Differential Diagnosis
73Other Anomalies in Excretion in Gout
179Retrocedent Gout
74Purin Metabolism in other Disorders
180Other Irregular Manifestations
75Purin Metabolism in Chronic Alcoholism and Plumbism
181Infantile Gout
76Infantile Gout
182Iritis.
77Anomalies in Uric Acid Excretion in Gout
183Radical Treatment of Local Foci of Infection or Toxic Absorption
78Uricæmia in Nephritis
184Diet
79Uric Acid, Urea N, and Creatinine of Blood in Gout and Early and Late Nephritis
185Regulation of Diet in the Gouty
80The Relationship, if any, between the Amounts of Uric Acid and of Urea, and Total Non-Protein Nitrogen in Human Blood
186The Individual Foodstuffs
81Uricæmia not Necessarily Due To Renal Defect
187Special Dietaries
82Uricæmia not Peculiar to Nephritis
188Beverages in Gout
83Uricæmia does not Necessarily Portend Gout
189Alcohol in Gout
84To what may be Ascribed the Deficient Eliminating Capacity of the Kidney for Uric Acid?
190The Various Alcoholic Beverages
85Uratic Deposits in Nephritis
191Medicinal Therapy
86Differentiation of Uratic Deposits in Gout and Nephritis
192Colchicum in Acute Gout.
87Clinical Associations of Gout and Granular Kidney
193Local Measures in Acute Gout.
88Folin and Denis’s Method
194Treatment in the Inter-paroxysmal Period
89Uric Acid a Normal Constituent of Blood
195Local Measures in Chronic Articular Gout
90Uric Acid, Total Non-Protein Nitrogen and Urea Nitrogen in Blood
196Treatment of Associated Morbid Conditions
91Uric Acid, Total Non-Protein Nitrogen and Urea Nitrogen in Blood
197Climate and Residence
92Effect of Exogenous Purines
198Exercise
93Uric Acid Content of Blood in Gout
199General Massage
94Hyper-Uricæmia in Non-Gouty Arthritis
200General Hydro-therapy
95Variations in Uric Acid Content of Blood Independently of Diet
201Methods of Application of General Hydro-therapy
96What Relation, if any, Exists between the Uric Acid Content of the Blood and Attacks of Gout?
202Methods of Local Hydro-therapy
97Discussion of the Foregoing Data
203Treatment by Hyperæmia
98Constitution of Tophi
204Mineral Springs
99Marchand’s Analysis
205Radio-active Waters
100Lehmann’s Analysis
206Influence on Uric Acid Metabolism
101Ebstein and Sprague’s Analysis
207Therapeutic Action and Application
102Mode of Formation
208Choice of Spa
103Localisation of Uratic Deposits
209Associated Morbid Conditions
104The Causation of Tophi
210Concluding Remarks on Spa Treatment
105Solubilities of Uric Acid
211Spas from a National Aspect
106Tophi in Relation To Uricæmia
