The Last Bus Out of Detroit follows Big Frankie Kowalski, a retired autoworker, as he boards the final Greyhound departing a fading Detroit. Accompanied by a small group of fellow passengers—an elderly knitter with her tiny dog, a young aspiring producer, a haunted veteran, and their veteran driver—they share raw, heartfelt stories of love, loss, survival, and the city that shaped them. Through laughter, tears, and quiet revelations on the long ride to Chicago, strangers become witnesses to one another’s endings and fragile new beginnings. In this tender, humorous road tale, leaving home becomes the bravest act of staying alive.